Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
RIP3 Recombinant Superclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 5
RIP3 Antibody (711691) in ICC/IF
For immunofluorescence analysis, HT-29 cells were fixed and permeabilized for detection of endogenous RIP3 using Anti-RIP3 Recombinant Rabbit Polyclonal Antibody (Product # 711691, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of RIP3 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938)... View More
产品信息
711691
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Peptide corresponding to human RIP3 (aa496-aa513)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2688314
产品详细信息
This antibody is predicted to react with Mouse, Rat, Horse
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3
基因别名: RIP3; RIPK3
UniProt ID: (Human) Q9Y572
Entrez Gene ID: (Human) 11035
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
cellular protein modification process
signal transduction
I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatase activity
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
NIK/NF-kappaB signaling
T cell homeostasis
regulation of activated T cell proliferation
protein autophosphorylation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
protein heterooligomerization
positive regulation of ligase activity
positive regulation of oxidoreductase activity
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
positive regulation of protein deacetylation
apoptotic signaling pathway
amyloid fibril formation
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
