Invitrogen

RNF183 Polyclonal Antibody

产品信息

PA5-63466

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human RNF183. Recombinant protein control fragment (Product #RP-99866).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2646650

产品详细信息

Immunogen sequence: ELEAECPVCW NPFNNTFHTP KMLDCCHSFC VECLAHLSLV TPARRRLLCP LCRQPTVLAS GQPVTDLPTD

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.

靶标信息

Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。