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RNF213 is an E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ALK lymphoma oligomerization partner on chromosome 17; E3 ubiquitin-lipopolysaccharide ligase RNF213; E3 ubiquitin-protein ligase RNF213; Mysterin; protein ALO17; RING finger protein 213
基因别名: 6030403J01; ALO17; C17orf27; D11Ertd759e; KIAA1554; KIAA1618; mKIAA1554; MYMY2; MYSTR; NET57; RGD1308168; RNF213
UniProt ID: (Human) C9JCP4
Entrez Gene ID: (Human) 57674, (Rat) 303735, (Mouse) 672511