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Invitrogen
ROR2 Monoclonal Antibody (OTI3H3)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 5
ROR2 Antibody (MA5-27244) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human prostate tissue. To expose target proteins, heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min. Following antigen retrieval, tissues were probed with a ROR2 monoclonal antibody (Product # MA5-27244) at a dilution of 1:500.
产品信息
MA5-27244
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI3H3
抗原
Human recombinant protein fragment corresponding to amino acids 796-927 of ROR2 produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2725256
靶标信息
ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. It is thought to be involved in the early formation of the chondrocytes and cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: neurotrophic tyrosine kinase receptor-related 2; Neurotrophic tyrosine kinase, receptor-related 2; receptor tyrosine kinase-like orphan receptor 2; Tyrosine-protein kinase transmembrane receptor ROR2
基因别名: BDB; BDB1; NTRKR2; ROR2
UniProt ID: (Human) Q01974
Entrez Gene ID: (Human) 4920
cartilage condensation
somitogenesis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
Wnt signaling pathway, calcium modulating pathway
smoothened signaling pathway
JNK cascade
multicellular organism development
negative regulation of cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
BMP signaling pathway
embryonic genitalia morphogenesis
inner ear morphogenesis
embryonic digit morphogenesis
cell fate commitment
positive regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
