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产品信息
CF806996
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI1G1
抗原
Human recombinant protein fragment corresponding to amino acids 1-260 of human RORB produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain.
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生物信息学
蛋白别名: nuclear receptor RZR-beta; nuclear receptor subfamily 1 group F member 2; RAR-related orphan receptor B; RAR-related orphan receptor beta; retinoic acid-binding receptor beta; retinoid-related orphan receptor beta; retinoid-related orphan receptor-beta
基因别名: bA133M9.1; NR1F2; ROR-BETA; RZR-BETA; RZRB
Entrez Gene ID: (Human) 6096
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
melatonin receptor activity
sequence-specific DNA binding
C4 zinc finger nuclear receptor
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
G-protein coupled receptor signaling pathway
brain development
visual perception
circadian rhythm
intracellular receptor signaling pathway
amacrine cell differentiation
eye photoreceptor cell development
regulation of circadian rhythm
steroid hormone mediated signaling pathway
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
retinal rod cell development
retinal cone cell development
retina development in camera-type eye
cellular response to retinoic acid
