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产品信息
PA5-96153
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-243 of human RPS3 (NP_0009962)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807955
产品详细信息
Immunogen sequence: MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG VLGIKVKIML PWDPTGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV PTA; Positive Samples: CEM, MCF-7, SW620, HT-29, Mouse liver, Mouse brain, Mouse heart; Cellular Location: Cytoplasm, Mitochondrion inner membrane, Nucleus, Peripheral membrane protein, cytoskeleton, nucleolus, spindle
靶标信息
WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; OTTHUMP00000229804; OTTHUMP00000229805; OTTHUMP00000229874; OTTHUMP00000229877; OTTHUMP00000229878; OTTHUMP00000229879; OTTHUMP00000229880; OTTHUMP00000229882; OTTHUMP00000229883; OTTHUMP00000229886; Small ribosomal subunit protein uS3
基因别名: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3
UniProt ID: (Human) P23396, (Mouse) P62908, (Rat) P62909
Entrez Gene ID: (Human) 6188, (Mouse) 27050, (Rat) 140654
DNA binding
damaged DNA binding
RNA binding
mRNA binding
structural constituent of ribosome
DNA-(apurinic or apyrimidinic site) lyase activity
endodeoxyribonuclease activity
protein binding
microtubule binding
transcription factor binding
tubulin binding
DNA N-glycosylase activity
enzyme binding
kinase binding
protein kinase binding
Hsp70 protein binding
SUMO binding
oxidized purine DNA binding
oxidized pyrimidine DNA binding
ubiquitin-like protein conjugating enzyme binding
poly(A) RNA binding
protein kinase A binding
iron-sulfur cluster binding
Hsp90 protein binding
small ribosomal subunit rRNA binding
supercoiled DNA binding
nucleic acid binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
lyase activity
NF-kappaB binding
ribosomal protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
translation
translational initiation
SRP-dependent cotranslational protein targeting to membrane
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
chromosome segregation
mitotic nuclear division
positive regulation of gene expression
negative regulation of translation
viral transcription
positive regulation of microtubule polymerization
negative regulation of protein ubiquitination
positive regulation of endodeoxyribonuclease activity
DNA damage response, detection of DNA damage
regulation of apoptotic process
positive regulation of JUN kinase activity
negative regulation of DNA repair
positive regulation of DNA repair
spindle assembly
cell division
response to TNF agonist
cellular response to hydrogen peroxide
positive regulation of NIK/NF-kappaB signaling
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA N-glycosylase activity
positive regulation of base-excision repair
positive regulation of apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
DNA metabolic process
regulation of translation
cell cycle
positive regulation of NF-kappaB transcription factor activity
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
cytoplasmic translation
