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RSPO1 Antibody (PA5-20749) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using RSPO1 Polyclonal Antibody (Product # PA5-20749) at 2.5 µg/mL. Tissue was fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4˚C. A goat anti-rabbit IgG H&L (HRP) at 1/250 was used as secondary... View More
产品信息
PA5-20749
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid peptide from near the amino terminus of human RSPO1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152354
产品详细信息
A suggested positive control is rat spleen tissue lysate.
PA5-20749 can be used with blocking peptide PEP-0863.
靶标信息
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cristin-3; Cysteine-rich and single thrombospondin domain-containing protein 3; FLJ40906; hRspo1; mCristin-3; R-spondin homolog; R-spondin-1; Roof plate-specific spondin-1; RP11-566C13.1; thrombospondin type 1 domain containing gene Rspondin
基因别名: CRISTIN3; R-spondin; RSPO; RSPO1; Rspondin
UniProt ID: (Human) Q2MKA7, (Mouse) Q9Z132
Entrez Gene ID: (Human) 284654, (Mouse) 192199
positive regulation of protein phosphorylation
regulation of receptor internalization
Wnt signaling pathway
positive regulation of Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
male meiosis
regulation of gene expression
response to stimulus
canonical Wnt signaling pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of male germ cell proliferation
