Invitrogen

RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (ARC1162)

查看其他3个RUNX1/RUNX2/RUNX3抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

MA5-35649

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ARC1162

抗原

A synthetic peptide corresponding to a sequence within amino acids 354-453 of human RUNX1/2/3 (NP_0010018901)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.28 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2849549

产品详细信息

Immunogen sequence: LPPPYPGSSQ AQGGPFQASS PSYHLYYGAS AGSYQFSMVG GERSPPRILP PCTNASTGSA LLNPSLPNQS DVVEAEGSHS NSPTNMAPSA RLEEAVWRPY

靶标信息

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are welldocumented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; Acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AKV core binding factor; AML1-EVI-1 fusion protein; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; core binding factor alpha 1; core binding factor alpha 2; core binding factor alpha 3; Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; Core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; Oncogene AML-1; Oncogene AML-2; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2 alpha C; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha A; PEBP2 alpha C; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt domain, alpha subunit 3; Runt-related transcription factor 1; Runt-related transcription factor 2; Runt-related transcription factor 3; RUNX 2; RUNX-2; RUNX1/ZNF687 fusion; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor; transcription factor AML2; transcription factor AML2/CBFA3

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基因别名: AML1; AML1-EVI-1; AML2; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CBFA3; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2aA; PEBP2A; Pebp2a1; Pebp2a2; PEBP2A3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; Pebpa2a; Pebpa2b; RUNX1; RUNX2; RUNX3

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UniProt ID: (Human) Q01196, (Human) Q13950, (Human) Q13761, (Mouse) Q08775

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Entrez Gene ID: (Human) 861, (Human) 860, (Human) 864, (Mouse) 12394, (Mouse) 12393, (Mouse) 12399

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功能
regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding ATP binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein domain specific binding histone deacetylase binding bHLH transcription factor binding repressing transcription factor binding DNA binding calcium ion binding transcription factor binding protein homodimerization activity protein heterodimerization activity transcription regulatory region DNA binding Runt transcription factor DNA-binding transcription factor immunoglobulin fold transcription factor gene-specific transcriptional regulator
参与通路
ossification chondrocyte differentiation transcription from RNA polymerase II promoter hemopoiesis positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development hematopoietic stem cell proliferation osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte development osteoblast development regulation of transcription from RNA polymerase II promoter positive regulation of cell proliferation neuron differentiation T cell differentiation BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth cellular response to fibroblast growth factor stimulus regulation of cell differentiation positive regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated cell maturation embryonic cranial skeleton morphogenesis stem cell differentiation cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated protein phosphorylation negative regulation of cell cycle negative regulation of epithelial cell proliferation response to transforming growth factor beta skeletal system development in utero embryonic development liver development myeloid progenitor cell differentiation regulation of T cell anergy transcription, DNA-templated central nervous system development negative regulation of cell proliferation regulation of signal transduction myeloid cell differentiation negative regulation of granulocyte differentiation hair follicle morphogenesis response to retinoic acid positive regulation of interferon-gamma production embryonic hemopoiesis behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion positive regulation of gene expression regulation of ossification regulation of osteoblast differentiation positive regulation of ossification skeletal system morphogenesis axon guidance neuron projection development interferon-gamma production mRNA transcription from RNA polymerase II promoter positive regulation of extrinsic apoptotic signaling pathway
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