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Reelin Antibody (PA5-120595) in IHC (P)
Immunohistochemistry analysis of Reelin in paraffin-embedded mouse brain. Samples were incubated with Reelin Polyclonal antibody (Product # PA5-120595) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
PA5-120595
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 50-190 of human RELN (NP_005036.2).
偶联物
形式
Liquid
浓度
1.21 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914167
产品详细信息
Positive test controls include: U-87MG, C6, LO2, HepG2.
Immunogen sequence: KISTKNPDFL KDDFEGQLES DRFLLMSGGK PSRKCGILSS GNNLFFNEDG LRMLMTRDLD LSHARFVQFF MRLGCGKGVP DPRSQPVLLQ YSLNGGLSWS LLQEFLFSNS SNVGRYIALE IPLKARSGST RLRWWQPSEN GHFYSPWVID QILIGGNISG N
靶标信息
Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: extracellular matrix serine protease; Reeler protein; Reelin
基因别名: ETL7; LIS2; PRO1598; Reelen; reeler; RELN; RL
UniProt ID: (Human) P78509, (Mouse) Q60841, (Rat) P58751
Entrez Gene ID: (Human) 5649, (Mouse) 19699, (Rat) 24718
protein serine/threonine/tyrosine kinase activity
serine-type peptidase activity
metal ion binding
lipoprotein particle receptor binding
very-low-density lipoprotein particle receptor binding
protein binding
peptidase activity
hydrolase activity
molecular_function
cell adhesion molecule
extracellular matrix glycoprotein
extracellular matrix protein
cell morphogenesis involved in differentiation
neuron migration
proteolysis
cell adhesion
axon guidance
central nervous system development
brain development
long-term memory
associative learning
glial cell differentiation
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
dendrite development
peptidyl-tyrosine phosphorylation
spinal cord patterning
ventral spinal cord development
hippocampus development
cerebral cortex tangential migration
layer formation in cerebral cortex
positive regulation of TOR signaling
positive regulation of CREB transcription factor activity
reelin-mediated signaling pathway
positive regulation of protein kinase activity
response to pain
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
modulation of synaptic transmission
positive regulation of small GTPase mediated signal transduction
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
positive regulation of dendritic spine morphogenesis
positive regulation of protein tyrosine kinase activity
positive regulation of synapse maturation
NMDA glutamate receptor clustering
postsynaptic density protein 95 clustering
receptor localization to synapse
lateral motor column neuron migration
positive regulation of long-term synaptic potentiation
positive regulation of lateral motor column neuron migration
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
multicellular organism development
locomotory behavior
regulation of gene expression
cell migration
dentate gyrus development
cerebral cortex development
forebrain development
protein localization to synapse
thyroid hormone metabolic process
postsynaptic density assembly
midgut development
memory
response to mechanical stimulus
response to toxic substance
response to hormone
response to lithium ion
response to organic cyclic compound
response to insecticide
orbitofrontal cortex development
hypothalamus development
response to progesterone
social behavior
response to drug
response to amino acid
response to ethanol
response to axon injury
response to corticosterone
response to electrical stimulus
response to fatty acid
cellular response to dexamethasone stimulus
