NeoBiotechnologies

Reelin Monoclonal Antibody (RELN/4498)

查看其他8个Reelin抗体

抗体检测数据 (2)

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Reelin Antibody (19699-MSM1-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human kidney stained with Reelin Mouse Monoclonal Antibody (RELN/4498). Inset: PBS instead of primary antibody; secondary only negative control.

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Reelin Antibody in SDS-PAGE (SDS-PAGE)

Product Image Gallery

Reelin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human kidney stained with Reelin Mouse Monoclonal Antibody (RELN/4498). Inset: PBS instead of primary antibody; secondary only negative control.

Reelin Antibody in SDS-PAGE (SDS-PAGE) — SDS-PAGE analysis Purified REL Mouse Monoclonal Antibody (RELN/4498). Confirmation of Purity and Integrity of Antibody.

产品信息

19699-MSM1-P0

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

-

免疫组化（石蜡） (IHC (P))

Assay-dependent

-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

-

免疫细胞化学 (ICC/IF)

1-2 µg/mL

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

免疫沉淀 (IP)

1-2 µg/100-500 µg total protein

-

产品规格

种属反应

Human, Mouse, Rodent

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

RELN/4498

抗原

Recombinant fragment (around aa 1796-2115) of human RELN protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: extracellular matrix serine protease; Reeler protein; Reelin

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基因别名: ETL7; LIS2; PRO1598; reeler; RELN; RL

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UniProt ID: (Human) P78509, (Mouse) Q60841

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Entrez Gene ID: (Human) 5649, (Mouse) 19699

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protein serine/threonine/tyrosine kinase activity serine-type peptidase activity metal ion binding lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding protein binding peptidase activity hydrolase activity cell adhesion molecule extracellular matrix glycoprotein extracellular matrix protein

参与通路

cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion axon guidance central nervous system development brain development long-term memory associative learning glial cell differentiation positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development peptidyl-tyrosine phosphorylation spinal cord patterning ventral spinal cord development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex positive regulation of TOR signaling positive regulation of CREB transcription factor activity reelin-mediated signaling pathway positive regulation of protein kinase activity response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity multicellular organism development locomotory behavior regulation of gene expression cell migration dentate gyrus development cerebral cortex development forebrain development protein localization to synapse thyroid hormone metabolic process postsynaptic density assembly