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Immunogen sequence: MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCCKVL; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: aplysia ras-related homolog B; ras homolog B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; Rho-related GTP-binding protein RhoB; rhoB
基因别名: AA017882; Arh6; Arhb; Rhob
UniProt ID: (Rat) P62747, (Mouse) P62746
Entrez Gene ID: (Rat) 64373, (Mouse) 11852
分子生物学功能:
small GTPase