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产品信息
PA5-120679
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human S100A10 (NP_002957.1).
偶联物
形式
Liquid
浓度
1.32 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914251
产品详细信息
Positive test controls include: Rat lung.
Immunogen sequence: MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK
靶标信息
The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: annexin II ligand; annexin II ligand, calpactin I, light polypeptide; annexin II tetramer (AIIt) p11 subunit; calcium binding protein A11 (calgizzarin); Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; MGC111133; MGC133268; Nerve growth factor-induced protein 42C; OTTHUMP00000015270; P PRSS26; p10 protein; p11; p11 subunit; Protein S100 A10; Protein S100-A10; S-100 related protein, clone 42C; S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); S100 calcium binding protein A10 (calgizzarin); S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
基因别名: 42C; AA409961; AL024248; ANX2L; ANX2LG; Ca[1]; CAL12; CAL1L; CLP11; GP11; p10; P11; S100A10
UniProt ID: (Human) P60903, (Rat) P05943, (Mouse) P08207
Entrez Gene ID: (Human) 6281, (Rat) 81778, (Mouse) 20194
membrane raft assembly
membrane budding
positive regulation of GTPase activity
positive regulation of binding
protein heterotetramerization
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
positive regulation of substrate adhesion-dependent cell spreading
regulation of cell growth
response to antidepressant
regulation of cell differentiation
cellular response to acid chemical
