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Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Calvasculin; fibroblast-specific protein-1; leukemia multidrug resistance associated protein; malignant transformation suppression 1; Metastasin; Metastatic cell protein; PEL98; Placental calcium-binding protein; pr; Protein 18A2; Protein Mts1; Protein S100-A4; S100 calcium-binding protein A4; S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)
基因别名: 18A2; 42A; CAPL; FSP1; metastasin; MTS1; P9KA; PEL98; pk9a; S100A4
UniProt ID: (Human) P26447, (Mouse) P07091
Entrez Gene ID: (Human) 6275, (Mouse) 20198
分子生物学功能: calmodulin-related