Product References
Sphingosine 1-phosphate receptor 2 promotes the onset and progression of non-alcoholic fatty liver disease-related hepatocellular carcinoma through the PI3K/AKT/mTOR pathway.
Discover. Oncology
Wang G,Zhang X,Zhou Z,Song C,Jin W,Zhang H,Wu W,Yi Y,Cui H,Zhang P,Liu X,Xu W,Shen X,Shen W,Wang X
Wed Jan 11 00:00:00 EST 2023
Skeletal muscle insulin resistance and adipose tissue hypertrophy persist beyond the reshaping of gut microbiota in young rats fed a fructose-rich diet.
The Journal of nutritional biochemistry
Mazzoli A,Porzio AD,Gatto C,Crescenzo R,Nazzaro M,Spagnuolo MS,Baccigalupi L,Ricca E,Amoresano A,Fontanarosa C,Bernacchioni C,Donati C,Iossa S,Cigliano L
Wed Mar 01 00:00:00 EST 2023
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Chemico-biological interactions
Cui L,Li C,Zhang G,Zhang L,Yao G,Zhuo Y,Cui N,Zhang S
Tue Aug 01 00:00:00 EDT 2023
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Chemico-biological interactions
Cui L,Li C,Zhang G,Zhang L,Yao G,Zhuo Y,Cui N,Zhang S
Tue Aug 01 00:00:00 EDT 2023
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Chemico-biological interactions
Cui L,Li C,Zhang G,Zhang L,Yao G,Zhuo Y,Cui N,Zhang S
Tue Aug 01 00:00:00 EDT 2023
Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.
Neural regeneration research
Yang LX,Yao YY,Yang JR,Cheng HL,Zhu XJ,Zhang ZJ
Tue Aug 01 00:00:00 EDT 2023
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Liao Y,Zhou C,Duan Y,Liu X,Yue J,Li X,Wu J,Wan C,Zhang L
Mon May 01 00:00:00 EDT 2023
circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis.
Frontiers in cell and developmental biology
Zhang Z,Xia F,Yao L,Jiang B,Li X
Tue Apr 05 00:00:00 EDT 2022
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Cellular signalling
Pan D,Wu W,Zuo G,Xie X,Li H,Ren X,Kong C,Zhou W,Zhang Z,Waterfall M,Chen S
Sat Oct 01 00:00:00 EDT 2022
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Andrology
Liu K,Sun T,Luan Y,Chen Y,Song J,Ling L,Yuan P,Li R,Cui K,Ruan Y,Lan R,Wang T,Wang S,Liu J,Rao K
Tue Feb 01 00:00:00 EST 2022
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization.
Biochemical pharmacology
Wang X,Chen S,Xiang H,Wang X,Xiao J,Zhao S,Shu Z,Ouyang J,Liang Z,Deng M,Chen X,Zhang J,Liu H,Quan Q,Gao P,Fan J,Chen AF,Lu H
Fri Jul 01 00:00:00 EDT 2022
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization.
Biochemical pharmacology
Wang X,Chen S,Xiang H,Wang X,Xiao J,Zhao S,Shu Z,Ouyang J,Liang Z,Deng M,Chen X,Zhang J,Liu H,Quan Q,Gao P,Fan J,Chen AF,Lu H
Fri Jul 01 00:00:00 EDT 2022
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
Theranostics
Zhou C,Kuang Y,Li Q,Duan Y,Liu X,Yue J,Chen X,Liu J,Zhang Y,Zhang L
Mon Jul 18 00:00:00 EDT 2022
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.
Bioengineered
Chen T,Gu K,Lin R,Liu Y,Shan Y
Sun May 01 00:00:00 EDT 2022
Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis.
Journal of ethnopharmacology
Wang R,Ren Q,Gao D,Paudel YN,Li X,Wang L,Zhang P,Wang B,Shang X,Jin M
Tue May 10 00:00:00 EDT 2022
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury.
Stem cell reports
Wu Q,Xu X,Miao X,Bao X,Li X,Xiang L,Wang W,Du S,Lu Y,Wang X,Yang D,Zhang J,Shen X,Li F,Lu S,Fan Y,Xu S,Chen Z,Wang Y,Teng H,Huang Z
Tue Mar 08 00:00:00 EST 2022
Protective Effects of Complement Component 8 Gamma Against Blood-Brain Barrier Breakdown.
Frontiers in physiology
Kim JH,Han J,Suk K
Tue Jun 22 00:00:00 EDT 2021
Nogo-A regulates myogenesis via interacting with Filamin-C.
Cell death discovery
Park S,Park JH,Kang UB,Choi SK,Elfadl A,Ullah HMA,Chung MJ,Son JY,Yun HH,Park JM,Yim JH,Jung SJ,Kim SH,Choi YC,Kim DS,Shin JH,Park JS,Hur K,Lee SH,Lee EJ,Hwang D,Jeong KS
Wed Jan 06 00:00:00 EST 2021
Nogo-A regulates myogenesis via interacting with Filamin-C.
Cell death discovery
Park S,Park JH,Kang UB,Choi SK,Elfadl A,Ullah HMA,Chung MJ,Son JY,Yun HH,Park JM,Yim JH,Jung SJ,Kim SH,Choi YC,Kim DS,Shin JH,Park JS,Hur K,Lee SH,Lee EJ,Hwang D,Jeong KS
Wed Jan 06 00:00:00 EST 2021
Sphingosine 1-phosphate signaling in uterine fibroids: implication in activin A pro-fibrotic effect.
Fertility and sterility
Bernacchioni C,Ciarmela P,Vannuzzi V,Greco S,Vannuccini S,Malentacchi F,Pellegrino P,Capezzuoli T,Sorbi F,Cencetti F,Bruni P,Donati C,Petraglia F
Tue Jun 01 00:00:00 EDT 2021
Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.
Molecular medicine reports
Zhang T,Guo D,Zheng W,Dai Q
Tue Jun 01 00:00:00 EDT 2021
Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR.
EMBO molecular medicine
Zhu N,Zhang C,Prakash A,Hou Z,Liu W,She W,Morris A,Sik Kim K
Fri Mar 05 00:00:00 EST 2021
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Clinical and experimental pharmacology & physiology
Wang M,Wu H,Wang R,Dai X,Deng R,Wang Y,Bu Y,Sun M,Zhang H
Sun Aug 01 00:00:00 EDT 2021
Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.
Clinical and experimental pharmacology & physiology
Wang M,Wu H,Wang R,Dai X,Deng R,Wang Y,Bu Y,Sun M,Zhang H
Sun Aug 01 00:00:00 EDT 2021
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Molecular medicine reports
Mao S,Jin J,Li Z,Yang W
Mon Feb 01 00:00:00 EST 2021
Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via modulating gut microbiota and lipid metabolism pathway.
Journal of ethnopharmacology
Song Y,Shan B,Zeng S,Zhang J,Jin C,Liao Z,Wang T,Zeng Q,He H,Wei F,Ai Z,Su D
Wed Feb 10 00:00:00 EST 2021
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Brain : a journal of neurology
Kim JH,Afridi R,Han J,Jung HG,Kim SC,Hwang EM,Shim HS,Ryu H,Choe Y,Hoe HS,Suk K
Wed Mar 03 00:00:00 EST 2021
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Brain : a journal of neurology
Kim JH,Afridi R,Han J,Jung HG,Kim SC,Hwang EM,Shim HS,Ryu H,Choe Y,Hoe HS,Suk K
Wed Mar 03 00:00:00 EST 2021
Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
Brain : a journal of neurology
Kim JH,Afridi R,Han J,Jung HG,Kim SC,Hwang EM,Shim HS,Ryu H,Choe Y,Hoe HS,Suk K
Wed Mar 03 00:00:00 EST 2021
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Brain research
Matsumoto N,Yamashita T,Shang J,Feng T,Osakada Y,Sasaki R,Tadokoro K,Nomura E,Tsunoda K,Omote Y,Takemoto M,Hishikawa N,Ohta Y,Abe K
Wed Jul 15 00:00:00 EDT 2020
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice.
Brain research
Matsumoto N,Yamashita T,Shang J,Feng T,Osakada Y,Sasaki R,Tadokoro K,Nomura E,Tsunoda K,Omote Y,Takemoto M,Hishikawa N,Ohta Y,Abe K
Wed Jul 15 00:00:00 EDT 2020
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type ¿ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Andrology
Liu K,Cui K,Feng H,Li R,Lin H,Chen Y,Zhang Y,Chen Z,Yuan H,Li M,Wang T,Lan R,Liu J,Rao K,Wen B
Sun Mar 01 00:00:00 EST 2020
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type ¿ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Andrology
Liu K,Cui K,Feng H,Li R,Lin H,Chen Y,Zhang Y,Chen Z,Yuan H,Li M,Wang T,Lan R,Liu J,Rao K,Wen B
Sun Mar 01 00:00:00 EST 2020
JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type ¿ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Andrology
Liu K,Cui K,Feng H,Li R,Lin H,Chen Y,Zhang Y,Chen Z,Yuan H,Li M,Wang T,Lan R,Liu J,Rao K,Wen B
Sun Mar 01 00:00:00 EST 2020
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Psychoneuroendocrinology
Shan B,Ai Z,Zeng S,Song Y,Song J,Zeng Q,Liao Z,Wang T,Huang C,Su D
Wed Jul 01 00:00:00 EDT 2020
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Psychoneuroendocrinology
Shan B,Ai Z,Zeng S,Song Y,Song J,Zeng Q,Liao Z,Wang T,Huang C,Su D
Wed Jul 01 00:00:00 EDT 2020
Targeting E. coli invasion of the blood-brain barrier for investigating the pathogenesis and therapeutic development of E. coli meningitis.
Cellular microbiology
Zhu N,Liu W,Prakash A,Zhang C,Kim KS
Thu Oct 01 00:00:00 EDT 2020
β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.
Oncogene
Bruno G,Cencetti F,Pini A,Tondo A,Cuzzubbo D,Fontani F,Strinna V,Buccoliero AM,Casazza G,Donati C,Filippi L,Bruni P,Favre C,Calvani M
Wed Jan 01 00:00:00 EST 2020
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Glia
Bao X,Xu X,Wu Q,Zhang J,Feng W,Yang D,Li F,Lu S,Liu H,Shen X,Zhang F,Xie C,Wu S,Lv Z,Wang W,Li H,Fang Y,Wang Y,Teng H,Huang Z
Tue Sep 01 00:00:00 EDT 2020
Sphingosine 1-phosphate promotes the proliferation of olfactory ensheathing cells through YAP signaling and participates in the formation of olfactory nerve layer.
Glia
Bao X,Xu X,Wu Q,Zhang J,Feng W,Yang D,Li F,Lu S,Liu H,Shen X,Zhang F,Xie C,Wu S,Lv Z,Wang W,Li H,Fang Y,Wang Y,Teng H,Huang Z
Tue Sep 01 00:00:00 EDT 2020
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
International immunopharmacology
Zheng Z,Zeng YZ,Ren K,Zhu X,Tan Y,Li Y,Li Q,Yi GH
Tue Jan 01 00:00:00 EST 2019
S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.
International immunopharmacology
Zheng Z,Zeng YZ,Ren K,Zhu X,Tan Y,Li Y,Li Q,Yi GH
Tue Jan 01 00:00:00 EST 2019
Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.
Liver international : official journal of the International Association for the Study of the Liver
Liu L,Panzitt K,Racedo S,Wagner M,Platzer W,Zaufel A,Theiler-Schwetz V,Obermayer-Pietsch B,Müller H,Höfler G,Heinemann A,Zollner G,Fickert P
Fri Nov 01 00:00:00 EDT 2019
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
Archives of biochemistry and biophysics
Tong S,Chen SC,Xu KY,Fang B,Wang SH,Wang JJ
Mon Apr 02 00:00:00 EDT 2018
14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling.
Archives of biochemistry and biophysics
Tong S,Chen SC,Xu KY,Fang B,Wang SH,Wang JJ
Mon Apr 02 00:00:00 EDT 2018
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Andrologia
Cui K,Li R,Chen R,Li M,Wang T,Yang J,Chen Z,Wang S,Liu J,Rao K
Thu Feb 01 00:00:00 EST 2018
Androgen deficiency impairs erectile function in rats through promotion of corporal fibrosis.
Andrologia
Cui K,Li R,Chen R,Li M,Wang T,Yang J,Chen Z,Wang S,Liu J,Rao K
Thu Feb 01 00:00:00 EST 2018
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
PloS one
Matsushima-Nishiwaki R,Yamada N,Fukuchi K,Kozawa O
Fri May 10 00:00:00 EDT 2019
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
PloS one
Matsushima-Nishiwaki R,Yamada N,Fukuchi K,Kozawa O
Fri May 10 00:00:00 EDT 2019
S1PR2 antagonist protects endothelial cells against high glucose-induced mitochondrial apoptosis through the Akt/GSK-3β signaling pathway.
Biochemical and biophysical research communications
Liu H,Peng H,Chen S,Liu Y,Xiang H,Chen R,Chen W,Zhao S,Chen P,Lu H
Sat Aug 26 00:00:00 EDT 2017
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Scientific reports
Ingham NJ,Carlisle F,Pearson S,Lewis MA,Buniello A,Chen J,Isaacson RL,Pass J,White JK,Dawson SJ,Steel KP
Thu Jul 07 00:00:00 EDT 2016
S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse.
Scientific reports
Ingham NJ,Carlisle F,Pearson S,Lewis MA,Buniello A,Chen J,Isaacson RL,Pass J,White JK,Dawson SJ,Steel KP
Thu Jul 07 00:00:00 EDT 2016
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
International endodontic journal
Pan HY,Yang H,Shao MY,Xu J,Zhang P,Cheng R,Hu T
Fri May 01 00:00:00 EDT 2015
Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.
International endodontic journal
Pan HY,Yang H,Shao MY,Xu J,Zhang P,Cheng R,Hu T
Fri May 01 00:00:00 EDT 2015
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Nature communications
Kim GS,Yang L,Zhang G,Zhao H,Selim M,McCullough LD,Kluk MJ,Sanchez T
Wed Aug 05 00:00:00 EDT 2015
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Nature communications
Kim GS,Yang L,Zhang G,Zhao H,Selim M,McCullough LD,Kluk MJ,Sanchez T
Wed Aug 05 00:00:00 EDT 2015
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Nature communications
Kim GS,Yang L,Zhang G,Zhao H,Selim M,McCullough LD,Kluk MJ,Sanchez T
Wed Aug 05 00:00:00 EDT 2015
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.
Nature communications
Kim GS,Yang L,Zhang G,Zhao H,Selim M,McCullough LD,Kluk MJ,Sanchez T
Wed Aug 05 00:00:00 EDT 2015
