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产品信息
PA1-737
产品规格
种属反应
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: C N(217) Q P Q T Q Y S A T P N Y T Y S N(233)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2285630
产品详细信息
PA1-737 detects secretory carrier membrane protein 5 (SCAMP 5) from rat brain extract.
PA1-737 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~25 kDa protein representing SCAMP 5 from rat brain extract.
PA1-737 immunizing peptide corresponds to amino acid residues 217-233 from rat SCAMP 5. This sequence is 94% conserved in mouse. PA1-737 immunizing peptide (Cat. # PEP-152) is available for use in neutralization and control experiments.
靶标信息
Secretory carrier membrane proteins (SCAMPs) are proteins that are components of post-Golgi membranes. These proteins are implicated to function in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments that are involved in the recycling of cell surface receptors and endocytosis. In neurons, SCAMPs are associated with synaptic vesicles, secretion granules and transporter vesicles. SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1-3 contain cytoplasmic N-terminal regions with NPF repeats. NPF repeats are found to interact with EH domain proteins that function in budding of transport vesicles from the plasma membrane or the Golgi complex. SCAMPs 4 and 5 lack the N-terminal NPF repeats. SCAMPs 1-4 are all ubiquitously coexpressed while SCAMP 5 is only detectable in the brain. Studies show that SCAMP 5 is expressed late in development which is coincident with expansion of mature synapses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Secretory carrier membrane protein 5; secretory carrier membrane protein 5-like; Secretory carrier-associated membrane protein 5
基因别名: Scamp5
UniProt ID: (Rat) Q9JKE3
Entrez Gene ID: (Rat) 65171
