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Invitrogen
SCD Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 5
SCD Antibody (PA5-75757) in ICC/IF
Immunofluorescence analysis of SCD Polyclonal Antibody was performed using 70% confluent log phase 3T3-L1 and 3T3-L1 cells differentiated to adipocytes. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with SCD Polyclonal Antibody (Product # PA5-75757) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ S... View More
产品信息
PA5-75757
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human SCD
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719485
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5., have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acyl-CoA desaturase; Acyl-CoA desaturase 1; asebia; Delta(9)-desaturase; Delta(9)-desaturase 1; Delta-9 desaturase; Delta-9 desaturase 1; delta-9-desaturase; Fatty acid desaturase; Fatty acid desaturase 1; HGNC:10571; hSCD1; OTTHUMP00000020280; predicted protein of HQ0998; PRO0998; PRO1933; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); Stearoyl-CoA desaturase 1; stearoyl-CoA desaturase opposite strand
基因别名: AA589638; ab; AI265570; FADS5; hSCD1; MSTP008; SCD; Scd-1; SCD1; SCDOS
UniProt ID: (Human) O00767, (Mouse) P13516, (Rat) P07308
Entrez Gene ID: (Human) 6319, (Mouse) 20249, (Rat) 246074
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
positive regulation of cholesterol esterification
cholesterol esterification
negative regulation of growth of symbiont in host
defense response to Gram-positive bacterium
white fat cell differentiation
brown fat cell differentiation
oxidation-reduction process
monounsaturated fatty acid biosynthetic process
lipid biosynthetic process
unsaturated fatty acid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
