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The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Sec1 family domain-containing protein 1; SLY1 homolog; Sly1p; Syntaxin-binding protein 1-like 2; vesicle transport-related protein
基因别名: 3110021P21Rik; C14orf163; FKSG23; KIAA0917; RA410; SCFD1; SLY1; SLY1P; STXBP1L2
UniProt ID: (Human) Q8WVM8, (Mouse) Q8BRF7
Entrez Gene ID: (Human) 23256, (Mouse) 76983