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产品信息
68273-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C2B3
抗原
Recombinant protein
偶联物
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: ATIAETEEKE KRFQEAMEML KKEHEALTIR GVDTVSRSSL EMSPLAPVNS HERRSKRRKR MSSGTEECGE DRLPKSDSED GPRAMNHLSL TRGLSRTSMK PRSSRGSIFT FRRRDLGSEA DFADDENSTA GESESHRTSL LVPWPLRRTS AQGQPSPGTS APGHALHGKK NSTVDCNGVV SLLGAGDPEA TSPGSHLLRP VMLEHPPDTT TPSEEPGGPQ MLTSQAPCVD GFEEPGARQR ALSAVSVLTS ALEELEESRH KCPPCWNRLA QRYLIWECCP LWMSIKQGVK LVV
靶标信息
Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Scn5a is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in Scn5a are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms of Scn5a. Voltage-gated sodium channesl (VGSCs) mediate regenerative cell membrane depolarization and conduction of electrical signalling in nerves and muscles. Expression of Scn5a is also detected in lymphocytes, glia, and fibroblasts. Further, Scn5a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn5a forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Functionally, Scn5a is responsible for the initial upstroke of the action potential and the channel inactivation is regulated by intracellular calcium levels. Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. Scn5a are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Diseases associated with SCN5A include Long Qt Syndrome-3 and Brugada Syndrome 1.
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生物信息学
蛋白别名: cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2VF1; CIN5; hH1; HH1CMD1E; LQT3SSS1CMPD2; RATRSKM2X; RH1; RSkM2; RSKM2X; Scn2x; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type V subunit alpha; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; voltage-gated sodium channel Nav1.5c; Voltage-gated sodium channel subunit alpha Nav1.5; voltage-gated sodium channel type V alpha polypeptide
基因别名: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SCAL; SCN5A; SSS1; VF1
UniProt ID: (Human) E9PEK2, (Rat) P15389
Entrez Gene ID: (Human) 6331, (Rabbit) 100009516, (Rat) 25665
voltage-gated sodium channel activity
protein binding
calmodulin binding
fibroblast growth factor binding
enzyme binding
protein kinase binding
protein domain specific binding
ankyrin binding
ubiquitin protein ligase binding
ion channel binding
nitric-oxide synthase binding
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated sodium channel activity involved in SA node cell action potential
scaffold protein binding
voltage-gated ion channel
regulation of heart rate
cardiac ventricle development
brainstem development
sodium ion transport
positive regulation of sodium ion transport
response to denervation involved in regulation of muscle adaptation
neuronal action potential
telencephalon development
cerebellum development
sodium ion transmembrane transport
odontogenesis of dentin-containing tooth
positive regulation of action potential
positive regulation of epithelial cell proliferation
membrane depolarization
cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of ventricular cardiac muscle cell membrane depolarization
cardiac conduction
cellular response to calcium ion
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
membrane depolarization during action potential
membrane depolarization during cardiac muscle cell action potential
SA node cell action potential
AV node cell action potential
bundle of His cell action potential
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
membrane depolarization during Purkinje myocyte cell action potential
membrane depolarization during bundle of His cell action potential
AV node cell to bundle of His cell communication
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transport
positive regulation of heart rate
response to organic cyclic compound
regulation of ion transmembrane transport
bundle of His cell to Purkinje myocyte communication
SA node cell to atrial cardiac muscle cell communication
