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产品信息
H00006386-M01
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2C12
抗原
SDCBP (NP_005616, 1 a.a. approximately 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND
靶标信息
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; syndecan binding protein (syntenin); Syndecan-binding protein 1; Syntenin-1; TACIP18
基因别名: MDA-9; MDA9; SDCBP; ST1; SYCL; TACIP18
UniProt ID: (Human) B7ZLN2
Entrez Gene ID: (Human) 6386
glycoprotein binding
frizzled binding
interleukin-5 receptor binding
protein binding
protein C-terminus binding
cytoskeletal adaptor activity
growth factor binding
neurexin family protein binding
identical protein binding
protein homodimerization activity
syndecan binding
ephrin receptor binding
protein heterodimerization activity
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
membrane trafficking regulatory protein
negative regulation of receptor internalization
protein targeting to membrane
substrate-dependent cell migration, cell extension
Ras protein signal transduction
chemical synaptic transmission
regulation of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
actin cytoskeleton organization
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of JNK cascade
ephrin receptor signaling pathway
cell-cell adhesion
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
