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产品信息
PA5-34387
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid synthetic peptide near the center of human SDHD
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551739
产品详细信息
A suggested positive control is EL4 cell lysate.
PA5-34387 can be used with blocking peptide PEP-1430.
靶标信息
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CII-4; CybS; Malate dehydrogenase [quinone] cytochrome b small subunit; QPs3; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Succinate dehydrogenase complex subunit D; succinate dehydrogenase complex subunit D integral membrane protein; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
基因别名: 3110001M13Rik; AVLL5809; C78570; CBT1; CII-4; CWS3; cybS; PGL; PGL1; PRO19626; QPs3; SDH4; SDHD
UniProt ID: (Human) O14521, (Rat) Q6PCT8, (Mouse) Q9CXV1
Entrez Gene ID: (Human) 6392, (Rat) 363061, (Mouse) 66925
