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Positive control: Hela cell lysate, K562 cell lysate, SH-SY5Y cell lysate, HepG2 cell lysate, 293T cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse liver tissue lysate, rat liver tissue lysate, human liver tissue lysate, mouse brain tissue lysate.
Predicted band size: 46 kDa
Subcellular Location: Endoplasmic reticulum membrane.
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hTP-1; membrane protein SEC62, S.cerevisiae, homolog of; SEC62 homolog; SEC62 preprotein translocation factor; TP-1; Translocation protein 1; Translocation protein SEC62
基因别名: 3100002M17Rik; Ab2-292; AI844545; AW545092; Dtrp1; HTP1; SEC62; TLOC1; TP-1
UniProt ID: (Human) Q99442, (Mouse) Q8BU14
Entrez Gene ID: (Human) 7095, (Mouse) 69276, (Rat) 294912