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产品信息
PA5-88333
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_0050563)
偶联物
形式
Liquid
浓度
1.795 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804837
产品详细信息
Immunogen sequence: SSDEEGSQDE SLDSKTTLTS DESVKDHTTA GRVVAGQIFL DSEESELESS IQEEEDSLKS QEGESVTEDI SFLESPNPEN KDYEEPKKVR KPALTAIEGT AHGEPCHFPF LFLDKEYDEC TSDGREDGRL WCATTYDYKA DEKWGFCETE EEAAKRRQMQ EAEMMYQTG; Positive Samples: BxPC-3, HepG2, 293T, Mouse kidney, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Single-pass type I membrane protein
靶标信息
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IBD2; Protein sel-1 homolog 1; sel-1 suppressor of lin-12-like 1; Sel-1L; Sel1 (suppressor of lin-12) 1 homolog; Suppressor of lin 12 (sel-1), C. elegans, homolog of; Suppressor of lin-12-like protein 1
基因别名: AW493766; mKIAA4137; PRO1063; SEL1-LIKE; Sel1h; SEL1L; SEL1L1; TSA305; UNQ128/PRO1063
UniProt ID: (Human) Q9UBV2, (Mouse) Q9Z2G6
Entrez Gene ID: (Human) 6400, (Mouse) 20338, (Rat) 314352
triglyceride metabolic process
Notch signaling pathway
protein secretion
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
ERAD pathway
protein stabilization
endoplasmic reticulum mannose trimming
response to endoplasmic reticulum stress
biological_process
