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产品信息
H00008482-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3D3
抗原
SEMA7A (NP_003603, 536 a.a. approximately 633 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: EPHKECPNPK PDKAPLQKVS LAPNSRYYLS CPMESRHATY SWRHKENVEQ SCEPGHQSPN CILFIENLTA QQYGHYFCEA QEGSYFREAQ HWQLLPED
靶标信息
CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors - plexin C1 and beta1 integrins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD108; CDw108; JMH blood group antigen; John Milton Hagen blood group H-Sema K1; John-Milton-Hargen human blood group Ag; MGC126692; MGC126696; sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A (JMH blood group); sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, 7A; Sema K1; Sema L; semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group); Semaphorin-7A; Semaphorin-K1; Semaphorin-L
基因别名: CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMA7A; SEMAK1; SEMAL
UniProt ID: (Human) O75326
Entrez Gene ID: (Human) 8482
osteoblast differentiation
neural crest cell migration
inflammatory response
immune response
integrin-mediated signaling pathway
olfactory lobe development
positive regulation of cell migration
positive regulation of axon extension
axon extension
negative regulation of axon extension involved in axon guidance
regulation of inflammatory response
negative chemotaxis
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
semaphorin-plexin signaling pathway
