Proteintech

SEPT2 Monoclonal Antibody (2F3B2)

SEPT2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 15

SEPT2 Antibody (60075-1-IG) in ICC/IF

IF result of anti-SEPT2 (60075-1-IG, 1:1000) with hTERT-RPE cell by Dr. Moshe Kim. Green: SEPT2. Blue: DNA. 1% PFA fixed.

SEPT2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

产品信息

60075-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:20,000-1:200,000

查看9篇已发表文章 9篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:2000

免疫细胞化学 (ICC/IF)

1:20-1:200

查看7篇已发表文章 7篇已发表文章

免疫沉淀 (IP)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2F3B2

抗原

SEPT2 Fusion Protein Ag1946 (1-361 aa encoded by BC014455)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MSKQQPTQF INPETPGYVG FANLPNQVHR KSVKKGFEFT LMVVGESGLG KSTLINSLFL TDLYPERVIS GAAEKIERTV QIEASTVEIE ERGVKLRLTV VDTPGYGDAI NCRDCFKTII SYIDEQFERY LHDESGLNRR HIIDNRVHCC FYFISPFGHG LKPLDVAFMK AIHNKVNIVP VIAKADTLTL KERERLKKRI LDEIEEHNIK IYHLPDAESD EDEDFKEQTR LLKASIPFSV VGSNQLIEAK GKKVRGRLYP WGVVEVENPE HNDFLKLRTM LITHMQDLQE VTQDLHYENF RSERLKRGGR KVENEDMNKD QILLEKEAEL RRMQEMIARM QAQMQMQMQG GDGDGGALGH HV (1-361 aa encoded by BC014455)

靶标信息

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. It is required for the progression through mitosis, and it forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, Septin 2 may be required for chromosome segregation and spindle elongation. Septin 2 also plays a role in ciliogenesis and collective cell movements.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Orai1 is an Entotic Ca²⁺ Channel for Non-Apoptotic Cell Death, Entosis in Cancer Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lee AR,Park CY

Mon May 01 00:00:00 EDT 2023

Septins promote caspase activity and coordinate mitochondrial apoptosis.

Cytoskeleton (Hoboken, N.J.)

Van Ngo H,Robertin S,Brokatzky D,Bielecka MK,Lobato-Márquez D,Torraca V,Mostowy S

Tue Sep 19 00:00:00 EDT 2023

Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance, but not maturation defects.

Blood advances

Cloos AS,Pollet H,Stommen A,Maja M,Lingurski M,Brichard B,Lambert C,Henriet P,Pierreux C,Pyr Dit Ruys S,Van Der Smissen P,Vikkula M,Gatto L,Martin M,Brouillard P,Vertommen D,Tyteca D

Tue Sep 12 00:00:00 EDT 2023

Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells.

The Journal of cell biology

Martins CS,Taveneau C,Castro-Linares G,Baibakov M,Buzhinsky N,Eroles M,Milanović V,Omi S,Pedelacq JD,Iv F,Bouillard L,Llewellyn A,Gomes M,Belhabib M,Kuzmić M,Verdier-Pinard P,Lee S,Badache A,Kumar S,Chandre C,Brasselet S,Rico F,Rossier O,Koenderink GH,Wenger J,Cabantous S,Mavrakis M

Mon Mar 06 00:00:00 EST 2023

Human septins organize as octamer-based filaments and mediate actin-membrane anchoring in cells.

The Journal of cell biology

Mon Mar 06 00:00:00 EST 2023

Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.

Molecular & cellular proteomics : MCP

Tshilenge KT,Aguirre CG,Bons J,Gerencser AA,Basisty N,Song S,Rose J,Lopez-Ramirez A,Naphade S,Loureiro A,Battistoni E,Milani M,Wehrfritz C,Holtz A,Hetz C,Mooney SD,Schilling B,Ellerby LM

Mon May 01 00:00:00 EDT 2023

Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.

Cell research

Wang L,Paudyal SC,Kang Y,Owa M,Liang FX,Spektor A,Knaut H,Sánchez I,Dynlacht BD

Tue Feb 01 00:00:00 EST 2022

Contribution of septins to human platelet structure and function.

iScience

Kim OV,Litvinov RI,Mordakhanova ER,Bi E,Vagin O,Weisel JW

Fri Jul 15 00:00:00 EDT 2022

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.

Neuron

Li H,Saucedo-Cuevas L,Yuan L,Ross D,Johansen A,Sands D,Stanley V,Guemez-Gamboa A,Gregor A,Evans T,Chen S,Tan L,Molina H,Sheets N,Shiryaev SA,Terskikh AV,Gladfelter AS,Shresta S,Xu Z,Gleeson JG

Wed Mar 20 00:00:00 EDT 2019

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.

Neuron

Li H,Saucedo-Cuevas L,Yuan L,Ross D,Johansen A,Sands D,Stanley V,Guemez-Gamboa A,Gregor A,Evans T,Chen S,Tan L,Molina H,Sheets N,Shiryaev SA,Terskikh AV,Gladfelter AS,Shresta S,Xu Z,Gleeson JG

Wed Mar 20 00:00:00 EDT 2019

A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.

Cytoskeleton (Hoboken, N.J.)

Lobato-Márquez D,Krokowski S,Sirianni A,Larrouy-Maumus G,Mostowy S

Tue Jan 01 00:00:00 EST 2019

A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.

Cytoskeleton (Hoboken, N.J.)

Lobato-Márquez D,Krokowski S,Sirianni A,Larrouy-Maumus G,Mostowy S

Tue Jan 01 00:00:00 EST 2019

A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.

Cytoskeleton (Hoboken, N.J.)

Lobato-Márquez D,Krokowski S,Sirianni A,Larrouy-Maumus G,Mostowy S

Tue Jan 01 00:00:00 EST 2019

A requirement for septins and the autophagy receptor p62 in the proliferation of intracellular Shigella.

Cytoskeleton (Hoboken, N.J.)

Lobato-Márquez D,Krokowski S,Sirianni A,Larrouy-Maumus G,Mostowy S

Tue Jan 01 00:00:00 EST 2019

Septins suppress the release of vaccinia virus from infected cells.

The Journal of cell biology

Pfanzelter J,Mostowy S,Way M

Mon Aug 06 00:00:00 EDT 2018

Septins suppress the release of vaccinia virus from infected cells.

The Journal of cell biology

Pfanzelter J,Mostowy S,Way M

Mon Aug 06 00:00:00 EDT 2018

Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.

Small GTPases

Farrugia AJ,Calvo F

Mon Jan 02 00:00:00 EST 2017

Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.

Small GTPases

Farrugia AJ,Calvo F

Mon Jan 02 00:00:00 EST 2017

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Cell reports

Calvo F,Ranftl R,Hooper S,Farrugia AJ,Moeendarbary E,Bruckbauer A,Batista F,Charras G,Sahai E

Tue Dec 29 00:00:00 EST 2015

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Cell reports

Calvo F,Ranftl R,Hooper S,Farrugia AJ,Moeendarbary E,Bruckbauer A,Batista F,Charras G,Sahai E

Tue Dec 29 00:00:00 EST 2015

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Cell reports

Calvo F,Ranftl R,Hooper S,Farrugia AJ,Moeendarbary E,Bruckbauer A,Batista F,Charras G,Sahai E

Tue Dec 29 00:00:00 EST 2015

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Cell reports

Calvo F,Ranftl R,Hooper S,Farrugia AJ,Moeendarbary E,Bruckbauer A,Batista F,Charras G,Sahai E

Tue Dec 29 00:00:00 EST 2015

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 EDT 2011

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.

Nature genetics

Garcia-Gonzalo FR,Corbit KC,Sirerol-Piquer MS,Ramaswami G,Otto EA,Noriega TR,Seol AD,Robinson JF,Bennett CL,Josifova DJ,García-Verdugo JM,Katsanis N,Hildebrandt F,Reiter JF

Sun Jul 03 00:00:00 EDT 2011

生物信息学

蛋白别名: 2-Sep; NEDD-5; Neural precursor cell expressed developmentally down-regulated protein 5; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed, developmentally down-regulated gene 5; Septin-2; Vascular endothelial cell specific protein 11

查看更多收起

基因别名: AW208991; DIFF6; hNedd5; KIAA0158; mKIAA0158; NEDD-5; NEDD5; Pnutl3; SEPT2; SEPTIN2; Vesp11

查看更多收起

UniProt ID: (Human) Q15019, (Mouse) P42208, (Rat) Q91Y81

查看更多收起

Entrez Gene ID: (Human) 4735, (Mouse) 18000, (Rat) 117515

查看更多收起

功能

protein binding GTP binding enzyme regulator activity protein complex scaffold cadherin binding involved in cell-cell adhesion nucleotide binding GTPase activity identical protein binding cytoskeletal protein

参与通路