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产品信息
MA5-37935
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2207
抗原
A synthetic peptide corresponding to a sequence within amino acids 900-1001 of human SERCA1/ATP2A1 (O14983)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897855
产品详细信息
Positive Samples: Mouse skeletal muscle
Immunogen sequence: ALSVLVTIEM CNALNSLSEN QSLLRMPPWV NIWLLGSICL SMSLHFLILY VDPLPMIFKL RALDLTQWLM VLKISLPVIG LDEILKFVAR NYLEDPEDER RK
靶标信息
ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
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生物信息学
蛋白别名: Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA; SERCA ATPase; SERCA1; SR Ca(2+)-ATPase 1
基因别名: Atp2a1; SERCA1
UniProt ID: (Mouse) Q8R429, (Rat) Q64578
Entrez Gene ID: (Mouse) 11937, (Rat) 116601
transport
ion transport
calcium ion transport
regulation of muscle contraction
regulation of striated muscle contraction
apoptotic mitochondrial changes
positive regulation of fast-twitch skeletal muscle fiber contraction
positive regulation of endoplasmic reticulum calcium ion concentration
negative regulation of endoplasmic reticulum calcium ion concentration
response to endoplasmic reticulum stress
response to peptide hormone
negative regulation of striated muscle contraction
positive regulation of mitochondrial calcium ion concentration
maintenance of mitochondrion location
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
sarcoplasmic reticulum calcium ion transport
calcium ion import
calcium ion transmembrane transport
relaxation of skeletal muscle
carbohydrate derivative transport
nucleotide transmembrane transport
metabolic process
