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产品信息
H00027244-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SESN1 (NP_055269.1, 1 a.a. approximately 551 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAEGENEVRW DGLCSRDSTT RETALENIRQ TILRKTEYLR SVKETPHRPS DGLSNTESSD GLNKLLAHLL MLSKRCPFKD VREKSEFILK SIQELGIRIP RPLGQGPSRF IPEKEILQVG SEDAQMHALF ADSFAALGRL DNITLVMVFH PQYLESFLKT QHYLLQMDGP LPLHYRHYIG IMAAARHQCS YLVNLHVNDF LHVGGDPKWL NGLENAPQKL QNLGELNKVL AHRPWLITKE HIEGLLKAEE HSWSLAELVH AVVLLTHYHS LASFTFGCGI SPEIHCDGGH TFRPPSVSNY CICDITNGNH SVDEMPVNSA ENVSVSDSFF EVEALMEKMR QLQECRDEEE ASQEEMASRF EIEKRESMFV FSSDDEEVTP ARAVSRHFED TSYGYKDFSR HGMHVPTFRV QDYCWEDHGY SLVNRLYPDV GQLIDEKFHI AYNLTYNTMA MHKDVDTSML RRAIWNYIHC MFGIRYDDYD YGEINQLLDR SFKVYIKTVV CTPEKVTKRM YDSFWRQFKH SEKVHVNLLL IEARMQAELL YALRAITRYM T
靶标信息
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p53 activated gene 26; p53 regulated PA26 nuclear protein; p53-regulated protein PA26; Sestrin-1
基因别名: PA26; SESN1; SEST1
UniProt ID: (Human) Q9Y6P5
Entrez Gene ID: (Human) 27244
