Proteintech

SETD6 Polyclonal Antibody

查看其他5个SETD6抗体

抗体检测数据 (1)

SETD6 Antibody in Western Blot (WB)

SETD6 Antibody in Western Blot (WB)

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SETD6 Antibody (24377-1-AP) in WB

RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 24377-1-AP ( SETD6 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

SETD6 Antibody in Western Blot (WB)

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SETD6 Antibody in Western Blot (WB) — RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 24377-1-AP ( SETD6 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

产品信息

24377-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SETD6 Fusion Protein Ag19485 (124-473 aa encoded by BC022451)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.57 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: PLLLALLHE LQAPASRWRP YFALWPELGR LEHPMFWPEE ERRCLLQGTG VPEAVEKDLA NISSEYQSIV LPFMEAHPDL FSLGVRSLEL YHQLVALVMA YSFQEPLEEE EDEKEPNSPV MVPAADILNH LANHNANLEY SANCLRMVAT QPIPKGHEIF NTYGQMANWQ LIHMYGFVEP YPDNTDDTAD IQMVTVREAA LQGTKTEAER HLVYERWDFL CKLEMVGEEG AFVIGREEVL TEEELTTTLK VLCMPAEEFR ELKDQDGGGD DKREEGSLTI TNIPKLKASW RQLLQNSVLL TLQTYATDLK TDQGLLSNKE VYAKLSWREQ QALQVRYGQK MILHQLLELT S (124-473 aa encoded by BC022451)

靶标信息

SETD6 (SET domain-containing protein 6) is a 473 amino acid protein that belongs to the SETD6 family. Containing one SET domain, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. SETD6 is a proteinlysine N-methyltransferase that specifically monomethylates "Lys-310" of the NFκB p65 subunit of NFκB complex, leading to down-regulate NFκB transcription factor activity. SETD6-mediated methylation renders NFκB p65 inert and attenuates NFκB p65-driven transcriptional programs, including inflammatory responses in primary immune cells. The SETD6-initiated lysine-methylation signaling cascade acts to restrain activation of NFκB-mediated inflammatory responses in diverse cell types.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: N-lysine methyltransferase SETD6; SET domain-containing protein 6

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基因别名: 0610039J04Rik; 3110004G14Rik; AI413388; C76402; SETD6

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UniProt ID: (Human) Q8TBK2, (Mouse) Q9CWY3

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Entrez Gene ID: (Human) 79918, (Mouse) 66083

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protein binding protein-lysine N-methyltransferase activity NF-kappaB binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity methyltransferase

参与通路

peptidyl-lysine monomethylation stem cell population maintenance negative regulation of NF-kappaB transcription factor activity histone lysine methylation stem cell differentiation regulation of inflammatory response methylation