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SETD8 Antibody (PA5-31467) in ICC/IF
SETD8 Polyclonal Antibody detects SETD8 protein at nucleus by immunofluorescent analysis. Sample: MCF-7 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SETD8 protein stained by SETD8 Polyclonal Antibody (Product # PA5-31467) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-31467
应用
建议稀释比
已发表文章
产品规格
种属反应
C. elegans,
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 122 and 371 of Human SETD8
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548940
产品详细信息
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (95%), Rat (93%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. It is also involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: H4-K20-HMTase; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; H4-K20-specific histone methyltransferase; H4K20-specific histone methyltransferase splice variant Set8b; Histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A; Lysine N-methyltransferase 5A; Lysine-specific methylase 5A; N-lysine methyltransferase KMT5A; N-lysine methyltransferase SETD8; PR-Set7; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8
基因别名: KMT5A; PR-Set7; PRSET7; SET07; SET8; SETD8
UniProt ID: (Human) Q9NQR1
Entrez Gene ID: (Human) 387893
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
mitotic nuclear division
peptidyl-lysine monomethylation
histone H4-K20 methylation
regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
cell division
regulation of signal transduction by p53 class mediator
