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产品信息
PA5-50757
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues near the C terminal of human seizure related 6 homolog (mouse)-like
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636209
产品详细信息
The antibody detects endogenous levels of total SEZ6L protein.
靶标信息
SEZ6L (seizure related 6 homolog-like) is a 1,024 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum. Widely expressed, SEZ6L is a candidate tumor suppressor gene and may contribute to specialized endoplasmic reticulum functions in neurons. SEZ6L contains three CUB domains and five sushi (CCP/SCR) domains, which may be involved in protein-protein interactions and signal transduction. The gene encoding SEZ6L is located on human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
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生物信息学
蛋白别名: acupuncture induced gene 1; Acupuncture-induced protein 1-L; Brain-specific receptor-like protein B; BSRP-B; Seizure 6-like protein; seizure related 6 homolog (mouse)-like; seizure related gene 6-like
基因别名: Acig1; AI843918; AIG1; Aig1l; AW539724; BSRP-B; KIAA0927; mKIAA0927; SEZ6L; UNQ2542/PRO6094
UniProt ID: (Human) Q9BYH1, (Mouse) Q6P1D5
Entrez Gene ID: (Human) 23544, (Mouse) 56747
