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产品信息
H00006421-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3B10
抗原
SFPQ (NP_005057, 269 a.a. approximately 361 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: EEKISDSEGF KANLSLLRRP GEKTYTQRCR LFVGNLPADI TEDEFKRLFA KYGEPGEVFI NKGKGFGFIK LESRALAEIA KAELDDTPMR GRQ
靶标信息
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 100 kDa DNA-pairing protein; DNA-binding p52/p100 complex, 100 kDa subunit; hPOMp100; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; protein phosphatase 1, regulatory subunit 140; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated); splicing factor proline/glutamine-rich; Splicing factor, proline- and glutamine-rich
基因别名: POMP100; PPP1R140; PSF; SFPQ
UniProt ID: (Human) P23246
Entrez Gene ID: (Human) 6421
nucleotide binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
chromatin binding
protein binding
histone deacetylase binding
transcription regulatory region DNA binding
poly(A) RNA binding
RNA metabolism protein
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
double-strand break repair via homologous recombination
transcription, DNA-templated
mRNA processing
RNA splicing
regulation of circadian rhythm
negative regulation of circadian rhythm
positive regulation of sister chromatid cohesion
negative regulation of transcription, DNA-templated
rhythmic process
histone H3 deacetylation
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
