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SFTPD Antibody (PA5-115988) in ICC/IF
Immunocytochemistry analysis of SFTPD in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115988) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115988
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SFTPD(Accession P35247), corresponding to amino acid residues F265-M315.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900622
产品详细信息
Antibody detects endogenous levels of total Surfactant protein D.
靶标信息
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-A and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Collectin-7; Collectin7; CP4; Lung surfactant protein D; PSP-D; PSP-D Surfactant protein D; pulmonary surfactant apoprotein; Pulmonary surfactant associated protein PSP-D; pulmonary surfactant protein D; Pulmonary surfactant-associated protein D; SFTP 4; surfactant associated protein D; Surfactant associated protein pulmonary 4; surfactant, pulmonary-associated protein D; surfactant-associated protein, pulmonary 4
基因别名: AI573415; COLEC7; PSP-D; PSPD; SFTP4; SFTPD; SP-D; SPD
UniProt ID: (Human) P35247, (Rat) P35248, (Mouse) P50404
Entrez Gene ID: (Human) 6441, (Rat) 25350, (Mouse) 20390
regulation of cytokine production
receptor-mediated endocytosis
respiratory gaseous exchange
negative regulation of T cell proliferation
defense response to bacterium
surfactant homeostasis
cellular protein metabolic process
negative regulation of interleukin-2 biosynthetic process
innate immune response
macrophage chemotaxis
lung alveolus development
positive regulation of phagocytosis
regulation of immune response
reactive oxygen species metabolic process
opsonization
response to corticosteroid
negative regulation of interleukin-2 production
negative regulation of phagocytosis
regulation of liquid surface tension
response to glucocorticoid
response to hyperoxia
response to growth factor
immune system process
