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SGK1 Antibody (711183) in WB
Western blot analysis was performed on Whole cell extracts (30 µg lysate) of LNCaP (Lane 1), DU 145 (Lane 2), MCF-7 (Lane 3) and tissue extracts of Mouse Liver (Lane 4), Mouse Kidney (Lane 5) and Mouse Lung (Lane 6). The blots were probed with Anti-SGK1 Recombinant Rabbit Polyclonal Antibody (Product # 711183, 2.5 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 52 kDa band corresponding to SGK1 was observed ac... View More
产品信息
711183
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
22HCLC
抗原
Protein corresponding to human SGK1 (aa1-084)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2723645
产品详细信息
This antibody is predicted to react with Monkey, Pig, Dog, Cat.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; serum and glucocorticoid-dependent protein kinase; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
基因别名: SGK; SGK1
UniProt ID: (Human) O00141, (Mouse) Q9WVC6
Entrez Gene ID: (Human) 6446, (Mouse) 20393
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
calcium channel regulator activity
protein binding
ATP binding
potassium channel regulator activity
sodium channel regulator activity
chloride channel regulator activity
3-phosphoinositide-dependent protein kinase binding
cofactor binding
tau protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein modifying enzyme
regulation of cell growth
protein phosphorylation
sodium ion transport
cellular sodium ion homeostasis
apoptotic process
response to stress
cellular response to DNA damage stimulus
microtubule depolymerization
long-term memory
regulation of blood pressure
visual learning
positive regulation of sodium ion transport
peptidyl-serine phosphorylation
positive regulation of cell growth
regulation of cell migration
negative regulation of microtubule polymerization
positive regulation of transporter activity
ion transmembrane transport
intracellular signal transduction
regulation of cell proliferation
regulation of apoptotic process
negative regulation of apoptotic process
glucocorticoid mediated signaling pathway
neuron projection morphogenesis
positive regulation of dendrite morphogenesis
regulation of catalytic activity
regulation of sequence-specific DNA binding transcription factor activity
regulation of cell cycle
regulation of gastric acid secretion
renal sodium ion absorption
phosphorylation
cellular response to insulin stimulus
regulation of protein localization
