Proteintech

SGMS1 Polyclonal Antibody

SGMS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SGMS1 Antibody (19050-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver using 19050-1-AP (SGMS1 antibody) at dilution of 1:50 (under 40x lens).

SGMS1 Antibody in Immunoprecipitation (IP)

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产品信息

19050-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

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免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SGMS1 Fusion Protein Ag5246 (1-145 aa encoded by BC042899)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.21 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MKEVVYWSP KKVADWLLEN AMPEYCEPLE HFTGQDLINL TQEDFKKPPL CRVSSDNGQR LLDMIETLKM EHHLEAHKNG HANGHLNIGV DIPTPDGSFS IKIKPNGMPN GYRKEMIKIP MPELERSQYP MEWGKTFLAF LYALSC (1-145 aa encoded by B C042899)

靶标信息

A bidirectional lipid cholinephosphotransferases capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and the inverse reaction. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. May not function strictly as a SM synthase. Inhibited by bacterial PC-phospholipase C inhibitor D609. Localized to Golgi apparatus; Golgi membrane; multi-pass membrane protein. Possibly present on Brain, heart, kidney, liver, muscle and stomach.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

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Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Komuro M,Nagane M,Fukuyama T,Luo X,Hiraki S,Miyanabe M,Ishikawa M,Niwa C,Murakami H,Okamoto M,Yamashita T

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Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein.

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Fri Nov 04 00:00:00 EDT 2022

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

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Sinha T,Naash MI,Al-Ubaidi MR

Fri Apr 24 00:00:00 EDT 2020

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Experimental neurology

Lu MH,Ji WL,Xu DE,Yao PP,Zhao XY,Wang ZT,Fang LP,Huang R,Lan LJ,Chen JB,Wang TH,Cheng LH,Xu RX,Liu CF,Puglielli L,Ma QH

Tue Jan 01 00:00:00 EST 2019

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Experimental neurology

Lu MH,Ji WL,Xu DE,Yao PP,Zhao XY,Wang ZT,Fang LP,Huang R,Lan LJ,Chen JB,Wang TH,Cheng LH,Xu RX,Liu CF,Puglielli L,Ma QH

Tue Jan 01 00:00:00 EST 2019

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Experimental neurology

Lu MH,Ji WL,Xu DE,Yao PP,Zhao XY,Wang ZT,Fang LP,Huang R,Lan LJ,Chen JB,Wang TH,Cheng LH,Xu RX,Liu CF,Puglielli L,Ma QH

Tue Jan 01 00:00:00 EST 2019

Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.

Experimental neurology

Lu MH,Ji WL,Xu DE,Yao PP,Zhao XY,Wang ZT,Fang LP,Huang R,Lan LJ,Chen JB,Wang TH,Cheng LH,Xu RX,Liu CF,Puglielli L,Ma QH

Tue Jan 01 00:00:00 EST 2019

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Cancer research

Tang YC,Yuwen H,Wang K,Bruno PM,Bullock K,Deik A,Santaguida S,Trakala M,Pfau SJ,Zhong N,Huang T,Wang L,Clish CB,Hemann MT,Amon A

Sun Oct 01 00:00:00 EDT 2017

Dysregulated sphingolipid metabolism in endometriosis.

The Journal of clinical endocrinology and metabolism

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Wed Oct 01 00:00:00 EDT 2014

Dysregulated sphingolipid metabolism in endometriosis.

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生物信息学

蛋白别名: Medulla oblongata-derived protein; MGC17342; mob-1; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23

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基因别名: 9530058O11Rik; AI841905; C80702; hmob33; MOB; MOB1; SGMS1; SMS1; Sor1; TMEM23

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UniProt ID: (Human) Q86VZ5, (Mouse) Q8VCQ6, (Rat) Q7TSX5

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Entrez Gene ID: (Human) 259230, (Mouse) 208449, (Rat) 353229

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功能

kinase activity sphingomyelin synthase activity ceramide cholinephosphotransferase activity transferase activity

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