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Peptide sequence: IHFCITLLHA RKRVAIQFLK DIRESVTQIM KNPKAKTTGM GAIYGMAQTT
Sequence homology: Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91%
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ13811; hSPL; S1PL; SP-lyase 1; Sphingosine-1-phosphate aldolase; Sphingosine-1-phosphate lyase 1; SPL 1
基因别名: KIAA1252; S1PL; SGPL1; SPL
UniProt ID: (Human) O95470
Entrez Gene ID: (Human) 8879