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Recommended positive controls: A549, HeLa, Jurkat, NT2D1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3BP-1; OTTHUMP00000028981; SH3 domain-binding protein 1; SH3-domain binding protein 1
基因别名: ARHGAP43; SH3BP1
UniProt ID: (Human) Q9Y3L3
Entrez Gene ID: (Human) 23616