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The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases, and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3BP-2; Abl-SH3 binding protein 2; FLJ42079; SH3 domain-binding protein 2; SH3-domain binding protein 2; TNFAIP3 interacting protein 2
基因别名: 3BP-2; 3BP2; CRBM; CRPM; RES4-23; SH3BP2
UniProt ID: (Human) P78314
Entrez Gene ID: (Human) 6452