Proteintech

SH3GL2 Polyclonal Antibody

SH3GL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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SH3GL2 Antibody (12435-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 12435-1-AP ( SH3GL2 antibody) at dilution of 1:100 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

SH3GL2 Antibody in Immunoprecipitation (IP)

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产品信息

12435-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SH3GL2 Fusion Protein Ag3114 (1-279 aa encoded by BC032825)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.28 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MSVAGLKKQ FHKATQKVSE KVGGAEGTKL DDDFKEMERK VDVTSRAVME IMTKTIEYLQ PNPASRAKLS MINTMSKIRG QEKGPGYPQA EALLAEAMLK FGRELGDDCN FGPALGEVGE AMRELSEVKD SLDIEVKQNF IDPLQNLHDK DLREIQHHLK KLEGRRLDFD YKKERQGKIP DEELRQALEK FDESKEIAES SMFNLLEMDI EQVSQLSALV QAQLEYHKQA VQILQQVTVR LEERIRQASS QPRREYQPKP RMSLEFPTGD STQPNGGLSH (1-279 aa encoded by BC032825)

靶标信息

Enables identical protein binding activity. Involved in negative regulation of blood-brain barrier permeability; negative regulation of gene expression; and negative regulation of protein phosphorylation. Located in perinuclear region of cytoplasm.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Bioinformatics Analysis and Experimental Identification of Immune-Related Genes and Immune Cells in the Progression of Retinoblastoma.

Investigative ophthalmology & visual science

Chen S,Chen X,Zhang P,Chen S,Wang X,Luo Q,Cui Z,Huang Y,Wan L,Hou X,Yao H,Liu X,He A,Jiang Z,Qiu J,Li Y,Yu K,Zhuang J

Mon Oct 03 00:00:00 EDT 2022

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior.

Neoplasia (New York, N.Y.)

Majumdar S,Gong EM,Di Vizio D,Dreyfuss J,Degraff DJ,Hager MH,Park PJ,Bellmunt J,Matusik RJ,Rosenberg JE,Adam RM

Mon Jul 01 00:00:00 EDT 2013

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior.

Neoplasia (New York, N.Y.)

Majumdar S,Gong EM,Di Vizio D,Dreyfuss J,Degraff DJ,Hager MH,Park PJ,Bellmunt J,Matusik RJ,Rosenberg JE,Adam RM

Mon Jul 01 00:00:00 EDT 2013

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior.

Neoplasia (New York, N.Y.)

Majumdar S,Gong EM,Di Vizio D,Dreyfuss J,Degraff DJ,Hager MH,Park PJ,Bellmunt J,Matusik RJ,Rosenberg JE,Adam RM

Mon Jul 01 00:00:00 EDT 2013

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior.

Neoplasia (New York, N.Y.)

Majumdar S,Gong EM,Di Vizio D,Dreyfuss J,Degraff DJ,Hager MH,Park PJ,Bellmunt J,Matusik RJ,Rosenberg JE,Adam RM

Mon Jul 01 00:00:00 EDT 2013

生物信息学

蛋白别名: bA335L15.1; bA335L15.1 (SH3-domain GRB2-like 2); EEN-B1; endophilin; endophilin A1; Endophilin A1 BAR domain; endophilin I; Endophilin-1; Endophilin-A1; FLJ20276; FLJ25015; SH3 domain containing GRB2 like 2; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 2; SH3p4

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基因别名: 9530001L19Rik; AI120490; AW555077; B930049H17Rik; CNSA2; EEN-B1; Een1; SH3D2A; SH3GL2; SH3P4; SH3PA

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UniProt ID: (Human) Q99962, (Mouse) Q62420, (Rat) O35179

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Entrez Gene ID: (Human) 6456, (Mouse) 20404, (Rat) 116743

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功能

protein binding lipid binding identical protein binding

参与通路

regulation of receptor internalization endocytosis synaptic vesicle endocytosis microtubule-based movement signal transduction central nervous system development antigen processing and presentation of exogenous peptide antigen via MHC class II negative regulation of epidermal growth factor receptor signaling pathway