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Invitrogen
SH3PXD2A Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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SH3PXD2A Antibody (PA5-58169) in WB
Western blot was performed using Anti-SH3PXD2A Polyclonal Antibody (Product # PA5-58169) and ~130 kDa band corresponding to SH3PXD2A was observed in HeLa and A-375 cells and not in SK-BR-3 which is reported to be negative. Membrane enriched extracts (30 µg lysate) of HeLa (Lane 1), A-375 (Lane 2) and SK-BR-3 (Lane 3) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001... View More
产品信息
PA5-58169
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2647251
产品详细信息
Immunogen sequence: PDPSGKELDT VPAKGRQNEG KSDSLEKIER RVQALNTVNQ SKKATPPIPS KPPGGFGKTS GTPAVKMRNG VRQVAVRPQS VFVSP
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 88%.
靶标信息
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adapter protein TKS5; adaptor protein TKS5; Five SH3 domain-containing protein; five SH3 domains; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains
基因别名: 2310014D11Rik; AA589508; AI256723; AI413738; C230050L11; EG329070; FISH; Gm5098; KIAA0418; SH3MD1; SH3PXD2A; TKS5; TSK5
UniProt ID: (Human) Q5TCZ1, (Mouse) O89032
Entrez Gene ID: (Human) 9644, (Rat) 309460, (Mouse) 14218
