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产品信息
MA5-47053
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1455
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human SHB. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2938125
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosinephosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf(SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SH2 domain-containing adapter protein B; SHB (Src homology 2 domain containing) adaptor protein B; SHB adaptor protein (a Src homology 2 protein); Src homology 2 domain containing adaptor protein B
基因别名: bA3J10.2; BC028832; SHB
UniProt ID: (Human) Q15464, (Mouse) Q6PD21
Entrez Gene ID: (Human) 6461, (Mouse) 230126
angiogenesis
apoptotic process
signal transduction
positive regulation of signal transduction
cell differentiation
vascular endothelial growth factor receptor signaling pathway
blood vessel development
negative regulation of protein kinase activity
multicellular organism development
hemopoiesis
B cell proliferation
positive regulation of T-helper cell differentiation
positive regulation of mitotic cell cycle
blood vessel morphogenesis
T cell receptor signaling pathway
hematopoietic stem cell proliferation
negative regulation of oocyte maturation
