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Immunogen sequence: DYNQLALTAR LFRPRLIIAG TSAYARLIDY ARMREVCDEV KAHLLADMAH ISGLVAAKVI PSPFKHADIV TTTTHKTLRG ARSGLIFYRK GVKAVDPKTG REIPYTFEDR INFAVFPSLQ GGPHNHAIAA VAVALKQACT PMFREYSLQV LKNARAMADA LLERGYSLVS GGTDNHLVLV DLRPKGLDGA RAERVLELVS ITANKNTCPG DRSAITPGGL RLGAPALTSR QFREDDFRRV VDFIDEGVNI GLEVKSKTAK LQDFKSFLLK DSETSQRLAN LRQRVEQFAR AFPMPGFDEH
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: epididymis secretory sperm binding protein Li 51e; GLY A+; glycine auxotroph A, human complement for hamster; Glycine hydroxymethyltransferase; serine aldolase; serine hydroxymethylase; serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase, mitochondrial; Serine methylase; SHMT; SHMT 2; threonine aldolase
基因别名: GLYA; HEL-S-51e; SHMT; SHMT2
UniProt ID: (Human) P34897
Entrez Gene ID: (Human) 6472, (Rat) 299857
分子生物学功能:
methyltransferase