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产品信息
BS-7934R-A350
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human SHOC2/Sur8
偶联物
激发/发射光谱
343/441 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein sur-8 homolog; Ras-binding protein SUR-8; RP11-348N5.2; SHOC2 leucine-rich repeat scaffold protein; soc-2 (suppressor of clear) homolog; soc-2 suppressor of clear homolog; suppressor of clear, C. elegans, homolog of
基因别名: AU017287; KIAA0862; mKIAA0862; SHOC2; SIAA0862; SOC2; SUR8
UniProt ID: (Human) A8K9W8, (Mouse) O88520, (Rat) Q6AYI5
Entrez Gene ID: (Human) 8036, (Mouse) 56392, (Rat) 309548
