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SIAH1 Antibody (PA5-88583) in WB
Western blot analysis of SIAH1 in extracts of various cell lines. Samples were incubated with SIAH1 Polyclonal antibody (Product # PA5-88583) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
产品信息
PA5-88583
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human SIAH1 (NP_0010066111)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805014
产品详细信息
Immunogen sequence: MTGKATPPSL YSWRGVLFTC LPAARTRKRK EMSRQTATAL PTGTSKCPPS QRVPALTGTT ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK VANSVLFPCK YASSGCEITL PHTEKADHEE LCEFRPYSCP CPGASCKWQG SLDAVMPHLM HQHKSITTLQ GEDIVFLATD INLPGAVDWV MMQSCFGFHF MLVLEKQEKY DGHQQFFAIV QLIGTRKQAE NFAYRLELNG HRRRLTWEAT PRSIHEGIAT AIMNSDCLVF DTSIAQLFAE NGNLGINVTI SMC; Positive Samples: BT-474, Mouse kidney; Cellular Location: Cytoplasm, Nucleus
靶标信息
This gene encodes a protein that is a member of the seven in absentia homolog family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase SIAH1A; E3 ubiquitin-protein ligase SIAH1B; FLJ08065; h HUMSIAH; hSIAH1; mSiah-1a; RING-type E3 ubiquitin transferase SIAH1; RING-type E3 ubiquitin transferase SIAH1A; RING-type E3 ubiquitin transferase SIAH1B; Seven in absentia homolog 1; Seven in absentia homolog 1a; Seven in absentia homolog 1b; Siah-1; Siah-1a; Siah-1b
基因别名: AA960570; AA982064; AI853500; HUMSIAH; siah-1b; SIAH1; SIAH1A; Siah1b; Sinh1a; Sinh1b
UniProt ID: (Human) Q8IUQ4, (Mouse) P61092, (Mouse) Q06985
Entrez Gene ID: (Human) 6477, (Mouse) 20437, (Mouse) 20438
ubiquitin-protein transferase activity
protein binding
protein C-terminus binding
zinc ion binding
ligase activity
identical protein binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
protein homodimerization activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
protein modifying enzyme
protein polyubiquitination
ubiquitin-dependent protein catabolic process
apoptotic process
cell cycle
spermatogenesis
nervous system development
axon guidance
anatomical structure morphogenesis
protein catabolic process
protein destabilization
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular protein metabolic process
neuron apoptotic process
positive regulation of intrinsic apoptotic signaling pathway
male meiosis I
multicellular organism development
post-embryonic development
protein ubiquitination
cell differentiation
regulation of multicellular organism growth
