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产品信息
51045-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
SIK1 Fusion Protein Ag3913 (423-769 aa encoded by BC038504)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ASCSGVFRP RPVSPSSLLD TAISEEARQG PGLEEEQDTQ ESLPSSTGRR HTLAEVSTRL SPLTAPCIVV SPSTTASPAE GTSSDSCLTF SASKSPAGLS GTPATQGLLG ACSPVRLASP FLGSQSATPV LQAQGGLGGA VLLPVSFQEG RRASDTSLTQ GLKAFRQQLR KTTRTKGFLG LNKIKGLARQ VCQVPASRAS RGGLSPFHAP AQSPGLHGGA AGSREGWSLL EEVLEQQRLL QLQHHPAAAP GCSQAPQPAP APFVIAPCDG PGAAPLPSTL LTSGLPLLPP PLLQTGASPV ASAAQLLDTH LHIGTGPTAL PAVPPPRLAR LAPGCEPLGL LQGDCEM (423-769 aa encoded by BC038504 )
靶标信息
SIK1 may mediate the physiological effects of LKB1, including its tumor suppressor function. SIK1 is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HRT-20; Myocardial SNF1-like kinase; Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase); Salt-inducible kinase 1; salt-inducible protein kinase 1; serine/threonine protein kinase; Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK; SIK-1; SNF1-like kinase
基因别名: EIEE30; MSK; SIK; SIK1; SNF1LK
UniProt ID: (Human) P57059, (Mouse) Q60670
Entrez Gene ID: (Human) 150094, (Mouse) 17691
magnesium ion binding
protein serine/threonine kinase activity
protein binding
ATP binding
cAMP response element binding protein binding
protein kinase binding
14-3-3 protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
histone deacetylase binding
metal ion binding
non-receptor serine/threonine protein kinase
regulation of sodium ion transport
protein phosphorylation
cell cycle
regulation of mitotic cell cycle
regulation of myotube differentiation
negative regulation of triglyceride biosynthetic process
negative regulation of CREB transcription factor activity
cellular response to hormone stimulus
intracellular signal transduction
entrainment of circadian clock by photoperiod
regulation of cell differentiation
negative regulation of gluconeogenesis
protein autophosphorylation
rhythmic process
cardiac muscle cell differentiation
positive regulation of anoikis
negative regulation of transcription from RNA polymerase II promoter
multicellular organism development
phosphorylation
cell differentiation
anoikis
