Search Thermo Fisher Scientific
Immunogen sequence: AEPVLKAHQS HSAEIESQID RICEMGEVMR KAVQVDDDQF CKIQEKLAQL ELENKELREL LSISSESLQA RKENSMD
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 90%.
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Suppressor of IKBKE 1; suppressor of IKK epsilon; Suppressor of IKK-epsilon
基因别名: SIKE; SIKE1
UniProt ID: (Human) Q9BRV8
Entrez Gene ID: (Human) 80143