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SIPA1 Antibody (PA5-28122) in IHC (P)
SIPA1 Polyclonal Antibody detects SIPA1 protein at weak membrane and cytosol on HBL435 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HBL435 xenograft. SIPA1 Polyclonal Antibody (Product # PA5-28122) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-28122
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region within amino acids 980 and 1042 of Human SIPA1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 40% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545598
产品详细信息
Recommended positive controls: SIPA1 tansfected 293T cell.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The product of this gene is a mitogen induced GTPase activating protein. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1
基因别名: SIPA1; SPA1
UniProt ID: (Human) Q96FS4
Entrez Gene ID: (Human) 6494, (Mouse) 20469
cytoskeleton organization
negative regulation of cell adhesion
signal transduction
cell proliferation
negative regulation of cell growth
intracellular signal transduction
cellular response to water deprivation
positive regulation of GTPase activity
negative regulation of cell cycle
regulation of small GTPase mediated signal transduction
regulation of cell cycle
