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SIRT2 Monoclonal Antibody (4B11)

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抗体检测数据 (1)

SIRT2 Antibody in Western Blot (WB)

SIRT2 Antibody in Western Blot (WB)

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SIRT2 Antibody (H00022933-M01) in WB

Western Blot analysis of SIRT2 expression in transfected 293T cell line by SIRT2 monoclonal antibody (M01), clone 4B11. Lane 1: SIRT2 transfected lysate(39.5 KDa). Lane 2: Non-transfected lysate. .

SIRT2 Antibody in Western Blot (WB)

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SIRT2 Antibody in Western Blot (WB) — Western Blot analysis of SIRT2 expression in transfected 293T cell line by SIRT2 monoclonal antibody (M01), clone 4B11. Lane 1: SIRT2 transfected lysate(39.5 KDa). Lane 2: Non-transfected lysate. .

产品信息

H00022933-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫细胞化学 (ICC/IF)

10-100 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

功能检测 (Functional)

1-5 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

4B11

抗原

SIRT2 (AAH03012, 128 a.a. approximately 227 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.41 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Product may be used with Western Blot (Transfected lysate).

Immunogen sequence: YTQNIDTLER IAGLEQEDLV EAHGTFYTSH CVSASCRHEY PLSWMKEKIF SEVTPKCEDC QSLVKPDIVF FGESLPARFF SCMQSDFLKV DLLLVMGTSL

靶标信息

The SIRT2 protein (also known as Sirtuin for Silent Mating Type Information 2-Homolog) is a NAD-dependent deacytylase (NDAC) that has been shown to control gene silencing, cell cycle, and DNA damage repair. It is believed that SIRT2 may act as a tumor suppressor in human gliomas and may also serve as a novel molecular marker for these cells. SIRT2 has also been shown to act as a redox sensor to help regulate muscle gene expression in response to food intake and exercise. SIRT2 acts in the phosphorylation cascade involving mitosis where SIRT2 is phosphorylated in late G2 phase, during M phase, and into cytokinesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein defatty-acylase sirtuin-2; Regulatory protein SIR2 homolog 2; silent information regulator 2; SIR2-like protein 2; sir2-related protein type 2; sirtuin type 2; sirtuin-2

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基因别名: SIR2; SIR2L; SIR2L2; SIRT2

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UniProt ID: (Human) Q8IXJ6

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Entrez Gene ID: (Human) 22933

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chromatin binding NAD+ ADP-ribosyltransferase activity histone deacetylase activity protein binding transcription factor binding zinc ion binding NAD-dependent histone deacetylase activity protein deacetylase activity NAD-dependent protein deacetylase activity histone acetyltransferase binding histone deacetylase binding tubulin deacetylase activity ubiquitin binding NAD-dependent histone deacetylase activity (H4-K16 specific) beta-tubulin binding NAD+ binding

参与通路

negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA chromatin silencing chromatin silencing at telomere transcription, DNA-templated protein ADP-ribosylation protein deacetylation autophagy mitotic nuclear division regulation of exit from mitosis negative regulation of cell proliferation negative regulation of autophagy negative regulation of peptidyl-threonine phosphorylation phosphatidylinositol 3-kinase signaling gene silencing histone deacetylation substantia nigra development myelination in peripheral nervous system regulation of myelination positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to oxidative stress peptidyl-lysine deacetylation cellular response to hepatocyte growth factor stimulus negative regulation of protein catabolic process regulation of phosphorylation negative regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding protein kinase B signaling cellular lipid catabolic process innate immune response negative regulation of fat cell differentiation positive regulation of meiotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway negative regulation of oligodendrocyte differentiation cell division meiotic cell cycle regulation of cell cycle response to redox state positive regulation of cell division positive regulation of attachment of spindle microtubules to kinetochore negative regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to caloric restriction negative regulation of oligodendrocyte progenitor proliferation histone H3 deacetylation histone H4 deacetylation cellular response to molecule of bacterial origin cellular response to hypoxia cellular response to epinephrine stimulus tubulin deacetylation positive regulation of execution phase of apoptosis positive regulation of oocyte maturation negative regulation of NLRP3 inflammasome complex assembly negative regulation of defense response to bacterium ripoptosome assembly involved in necroptotic process negative regulation of reactive oxygen species metabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia