Proteintech

SIRT5 Polyclonal Antibody

SIRT5 Antibody in Immunocytochemistry (ICC/IF)

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SIRT5 Antibody (15122-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 15122-1-AP (SIRT5 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

SIRT5 Antibody in Immunoprecipitation (IP)

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产品信息

15122-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看25篇已发表文章 25篇已发表文章

免疫组化 (IHC)

Assay-dependent

查看6篇已发表文章 6篇已发表文章

免疫细胞化学 (ICC/IF)

1:50-1:500

查看6篇已发表文章 6篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看4篇已发表文章 4篇已发表文章

产品规格

种属反应

Rat, Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

SIRT5 Fusion Protein Ag7195 (1-310 aa encoded by BC000126)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MRPLQIVPS RLISQLYCGL KPPASTRNQI CLKMARPSSS MADFRKFFAK AKHIVIISGA GVSAESGVPT FRGAGGYWRK WQAQDLATPL AFAHNPSRVW EFYHYRREVM GSKEPNAGHR AIAECETRLG KQGRRVVVIT QNIDELHRKA GTKNLLEIHG SLFKTRCTSC GVVAENYKSP ICPALSGKGA PEPGTQDASI PVEKLPRCEE AGCGGLLRPH VVWFGENLDP AILEEVDREL AHCDLCLVVG TSSVVYPAAM FAPQVAARGV PVAEFNTETT PATNRFRFHF QGPCGTTLPE ALACHENETV S (1-310 aa encoded by BC000126)

靶标信息

SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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