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产品信息
730092
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
抗原
34-302 of 310 of SIRT5 Protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2532891
产品详细信息
730092 is a biotinylated Fab fragment targeting SIRT5.
Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include: better specificity, animal origin-free formulation, and more lot-to-lot consistency.
靶标信息
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ36950; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; Regulatory protein SIR2 homolog 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIRT5; sirtuin type 5
基因别名: SIR2L5; SIRT5
UniProt ID: (Human) F5H5Z9
Entrez Gene ID: (Human) 23408
chromatin silencing
protein ADP-ribosylation
protein deacetylation
regulation of ketone biosynthetic process
negative regulation of cardiac muscle cell apoptotic process
response to nutrient levels
protein demalonylation
peptidyl-lysine demalonylation
protein desuccinylation
peptidyl-lysine desuccinylation
protein deglutarylation
peptidyl-lysine deglutarylation
negative regulation of reactive oxygen species metabolic process
