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产品信息
67257-1-IG
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
1F2B2
抗原
SIRT5 Fusion Protein Ag7743
偶联物
形式
Liquid
浓度
1000 µg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Aliquoting is unnecessary for -20°C storage.
靶标信息
SIRT5 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ36950; NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacylase sirtuin-5, mitochondrial; Regulatory protein SIR2 homolog 5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIRT5; sirtuin type 5
基因别名: SIR2L5; SIRT5
UniProt ID: (Human) F5H5Z9
Entrez Gene ID: (Human) 23408
chromatin silencing
protein ADP-ribosylation
protein deacetylation
regulation of ketone biosynthetic process
negative regulation of cardiac muscle cell apoptotic process
response to nutrient levels
protein demalonylation
peptidyl-lysine demalonylation
protein desuccinylation
peptidyl-lysine desuccinylation
protein deglutarylation
peptidyl-lysine deglutarylation
negative regulation of reactive oxygen species metabolic process
