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SIT Antibody (MA1-19285) in WB
Western blotting analysis of human SIT using mouse monoclonal antibody SIT-01 on lysates of Molt-4 and HEK-293T cells under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2µg/mL of mouse anti-SIT Monoclonal antibody (Product # MA1-192850) followed by IRDye800-conjugated anti-mouse secondary antibody. SIT was detected around 36kDa.
产品信息
MA1-19285
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
SIT-01
抗原
Bacterially produced, recombinant, intracellular fragment of human SIT.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2301877
产品详细信息
This antibody reacts with murine SIT.
Western Blot: Reducing conditions.
靶标信息
SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP-2 interacting transmembrane adaptor protein; SHP2 interacting transmembrane adaptor; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; Signaling threshold-regulating transmembrane adapter 1; suppression inducing transmembrane adaptor 1; Suppression-inducing transmembrane adapter 1
基因别名: SIT; SIT-R; SIT1
UniProt ID: (Human) Q9Y3P8
Entrez Gene ID: (Human) 27240
